1. Download and install oracle client from Oracle
yum install libaio
rpm -Uvh oracle-instantclient12.1-basic-
rpm -Uvh oracle-instantclient12.1-devel-
rpm -Uvh oracle-instantclient12.1-sqlplus-
  1. Add Oracle client to library path
echo "/usr/lib/oracle/12.1/client64/lib" >/etc/ld.so.conf.d/oracle.conf
  1. install epel repo via yum extra
yum install epel-release
  1. Install additional
yum install gcc python-pip.noarch python-devel
  1. Install cx_Oracle via pip
pip install cx_Oracle